Vaccination is a process in which, a milder form of the virus or a part of the virus is introduced into the body. This triggers the immune response, either afresh or through vaccination memory.” T-cells have receptors that bind to the epitope that is presented in conjunction with a large molecule called MHC on the surface of the infected cell. Vani Janakiraman said, “T-cells are an important part of the body’s immune response. The vaccines could be considered effective against the variants if there are less mutated epitopes in their spike proteins and, if the mutated epitopes can still induce an immune response comparable to that elicited by original/native epitopes.įurther, Dr. Efficacy against multiple variants can be assessed by firstanalysing the epitope sequences of various variants for mutations and if they can effectively trigger T-cells induced in the immunization process.” Vani Janakiraman, Assistant Professor, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, IIT Madras, said, “The efficacy of vaccines,in this case,different forms of spike protein based vaccines, depends on whether it can trigger not only the antibody response but also the T cell response. Highlighting the key findings of this research, Dr.
MugdhaMohkhedkar, Students from the Department of Biotechnology, IIT Madras, and Dr. The results of this computational study have recently been published in the reputed peer-reviewed journal BBA - Molecular Basis of Disease (), in a paper co-authored by Mr. Vani Janakiraman, Assistant Professor, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, IIT Madras. Understanding the effect of these variations on the immune response can give some clarity about the efficacy of vaccination against the variants of SARS COV- 2. In variants of SARS COV-2, there are molecular level changes to the spike protein of the virus, and these variations may include the regions of protein sequences that are recognized by T-cells called epitopes. The Researchers setout to find out what would be the response like if the post-vaccination infections were caused by a variant other than the original Wuhan strain incorporated in vaccine preparations.
SPIKE PROTEIN VACCINE VERIFICATION
While further experimental verification is called for, the researchers believe that the present spike protein vaccinations are likely to be efficacious against circulating variants of Coronavirus (SARS COV-2). The results of the IIT Madras study suggest that the attack by selected variants – Delta plus, Gamma, Zeta, Mink and Omicron – may be dealt with by vaccine-induced T-cell responses despite the compromised neutralising antibodies responses. Indian Institute of Technology Madras(IIT Madras) Researchers have shown that spike protein vaccines may be effective against multiple variants of the Coronavirus (SARS COV-2).
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